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KMID : 0369820080380050289
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Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 5 p.289 ~ p.293
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A Novel Clotrimazole-Ioaded Suppository with Effective Anti-tumor Activity
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Xuan Jing Ji
Kim Jong-Tae
Oh Dong-Hoon
Han Hong-Hee
Lee Won-Seok
Lee Jong-Sook
Rhee Jong-Dal
Yong Chul-Soon
Woo Jong-Soo
Kim Jung-Ae
Choi Han-Gon
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Abstract
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To develop a poloxamer-based solid suppository with poloxamer and polyethylene glycol mixtures, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and antitumor activity of clotrimazole delivered by the poloxamer-based suppository were performed. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol(70/30%)] with the melting point of about 32℃ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, the ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. It gave the more effective anti-tumor activity than conventional PEG-based suppository due to fast dissolution. Thus, the clotrimazole-Ioaded poloxamer-based solid suppository was an effective rectal dosage form with anti-tumor activity.
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KEYWORD
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Clotrimazole, Suppository, Anti-tumor activity
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